receptor channel meaning in English
受体通道
Examples
- Meanwhile , the splice variants of nr1 subunit could also produce differences in the properties of nmda receptor channel
Nr1不同的剪接变体也赋予nmda受体通道不同的功能特征。 - It is widely recognized that the nr1 subunit is essential to the functional nmda receptor channels , while various combinations of nr2 and nr1 subunits could endow nmda receptor channel with different functional properties
重组受体的研究表明： nr1亚单位是nmmda受体复合物的必需组分，而不同的nr2亚单位则可与nr1形成具有不同通道特征的nmda受体复合物。 - Excitotoxicity , associated with stroke and neurodegeneration , is triggered primarily by massive ca2 + influx arising from overactivation of glutamate receptor channels of the n - methyl - d - aspartate ( nmda ) subtype . although approaches to treatment of these disorders with antagonists of nmda receptor ( nr ) have been testified to be effective in animal models , successful therapy in humans was limited by the severe side effects of complete nr blockade for their space window and time window
已有的nr受体拮抗剂或阻断剂均为人工合成的小分子药物，能弥散通过血脑屏障(空间窗过大) ，作用选择性低，病变脑区及非病变脑区都会受到影响，而且由于神经元可逆性损害的“时间窗”极短，人们难以适时使用有效的神经保护药物，这些均导致已有的药物难以进入临床。